Article
Combined effects of genetic and environmental factors on insulin resistance associated with reduced fetal growth.
Diabetes - 1 Dec 2002
Jaquet Delphine, Trégouët David A, Godefroy Thierry, Nicaud Viviane, Chevenne Didi, Tiret Laurence, Czernichow Paul, Lévy-Marchal Claire
Abstract excerpt
It has been suggested that the insulin resistance (IR) associated with reduced fetal growth results from interactions between genetic factors and an unfavorable fetal environment. In addition, the adipose tissue seems to play a key role in this association. We investigated whether polymorphisms in tumor necrosis factor (TNF)-alpha(G-308A), beta3 adrenoreceptor (ADRB3)(G+250C), and peroxisome...
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