Article
Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment.
The Journal of clinical endocrinology and metabolism - 1 Jan 2016
Thankamony Ajay, Jensen Rikke Beck, O'Connell Susan M, Day Felix, Kirk Jeremy, Donaldson Malcolm, Ivarsson Sten A, Söder Olle, Roche Edna, Hoey Hilary, Ong Ken K, Dunger David B, Juul Anders
Abstract excerpt
BACKGROUND: Genetic susceptibility to insulin resistance is associated with lower adiposity in adults. Insulin resistance, and therefore adiposity, may alter sensitivity to GH. We aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to GH treatment in short children born small for gestational age (SGA). METHODS: In 89 short...
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