Article
The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.
The Journal of clinical endocrinology and metabolism - 1 Jun 2006
Vu-Hong Thuy-Ai, Durand Emmanuelle, Deghmoun Samia, Boutin Philippe, Meyre David, Chevenne Didier, Czernichow Paul, Froguel Philippe, Levy-Marchal Claire
Abstract excerpt
CONTEXT: Both adverse intrauterine events and genetic background have been suggested to promote insulin resistance in subjects born small for gestational age (SGA). Among candidate genes that potentially influence both fetal growth and glucose metabolism is insulin. The potential effect of the insulin gene VNTR (INS) on birth weight has been controversial so far. OBJECTIVE: The present association study aimed at...
Topics
- Adult
- Genotype
- Humans
- Infant, Newborn
- Infant, Small for Gestational Age
- Insulin
- Insulin Resistance
- Minisatellite Repeats