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Article

The popular herbal antimalarial, extract of Cryptolepis sanguinolenta, is potently cytotoxic.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2002

Ansah Charles, Gooderham Nigel J

Abstract excerpt

The aqueous root extract of Cryptolepis sanguinolenta (CSE) is a popular antimalarial in West African ethnomedicine. Cryptolepine (CLP), the major alkaloid of the plant, is a cytotoxic DNA intercalator that has promise as an anticancer agent. To date the aqueous root extract, the traditional antimalarial formulation, has not been evaluated for toxicity. In this study, we have examined the in vitro toxicity of CSE...

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PMID: 12441369
DOI: 10.1093/toxsci/70.2.245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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