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Article

The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells.

The Journal of biological chemistry - 24 Jan 2003

Ketteler Robin, Moghraby Chetal S, Hsiao Jonathan G, Sandra Olivier, Lodish Harvey F, Klingmüller Ursula

Abstract excerpt

The small cytokine-inducible SH2 domain-containing protein (CIS) has been implicated in the negative regulation of signaling through cytokine receptors. CIS reduces growth of erythropoietin receptor (EpoR)-dependent cell lines, but its role in proliferation, differentiation, and survival of erythroid progenitor cells has not been resolved. To dissect the function of CIS in cell lines and erythroid progenitor...

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PMID: 12441334
DOI: 10.1074/jbc.M211236200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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