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Article

Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.

Cellular signalling - 1 Feb 2017

Funakoshi-Tago Megumi, Moriwaki Takuro, Ueda Fumihito, Tamura Hiroomi, Kasahara Tadashi, Tago Kenji

Abstract excerpt

The JAK2 V617F mutant-mediated aberrant signaling pathway is a hallmark of myeloproliferative neoplasms (MPNs). Although cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are negative regulators of the JAK-STAT pathway, the functional role of CIS/SOCS family members in the JAK2 V617F mutant-induced oncogenic signaling pathway has not yet been elucidated. In this study,...

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Source

Identifiers

PMID: 28038963
DOI: 10.1016/j.cellsig.2016.12.008

Genes

JAK2
SOCS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.PMID 28038963Read ↗

The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells.Semantic proximity Read ↗

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