Article
Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity.
The pharmacogenomics journal - 1 Jan 2002
Acuña Gonzalo, Foernzler Dorothee, Leong Diane, Rabbia Michael, Smit Ralf, Dorflinger Ernest, Gasser Rodolfo, Hoh Josephine, Ott Jürg, Borroni Edilio, To Zung, Thompson Annick, Li Jia, Hashimoto Lara, Lindpaintner Klaus
Abstract excerpt
A retrospective pharmacogenetic study was conducted to identify possible genetic susceptibility factors in patients in whom the administration of the anti-Parkinson drug, tolcapone (TASMAR), was associated with hepatic toxicity. We studied 135 cases of patients with elevated liver transaminase levels (ELT) of >/=1.5 times above the upper limit of normal, in comparison with matched controls that had also received...
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