Article
Long-term ex vivo expansion of human fetal liver primitive haematopoietic progenitor cells in stroma-free cultures.
British journal of haematology - 1 Dec 2002
Peters Rowayda, Leyvraz Serge, Faes-Van't Hull Eveline, Jaunin Philippe, Gerber Stefan, Rollini Pierre
Abstract excerpt
Successful expansion of haematopoietic cells in ex vivo cultures will have important applications in transplantation, gene therapy, immunotherapy and potentially also in the production of non-haematopoietic cell types. Haematopoietic stem cells (HSC), with their capacity to both self-renew and differentiate into all blood lineages, represent the ideal target for expansion protocols. However, human HSC are rare,...
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