Article
Identification of the first fungal NADP-GAPDH from Kluyveromyces lactis.
Biochemistry - 19 Nov 2002
Verho Ritva, Richard Peter, Jonson Per Harald, Sundqvist Lena, Londesborough John, Penttilä Merja
Abstract excerpt
Deletion of the phosphoglucose isomerase gene, PGI1, in Saccharomyces cerevisiae leads to a phenotype for which glucose is toxic. This is related to overproduction of NADPH through the oxidative part of the pentose phosphate pathway and the incompetence of S. cerevisiae to deal with this overproduction. A similar deletion (rag2) in Kluyveromyces lactis does not lead to such a phenotype. We transformed a genomic...
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