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Parvovirus B19 transmission by heat‐treated clotting factor concentrates

1 Nov 2002

Abstract excerpt

BACKGROUND: Human parvovirus B19 (B19) DNA can be frequently detected in plasma-derived coagulation factor concentrates. The production of some clotting factor products includes heat treatment steps for virus inactivation, but the effectiveness of such steps for B19 inactivation is unclear. Moreover, detailed transmission case reports including DNA sequence analysis and quantification of B19 DNA from contaminated...

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PMID: 12421221
DOI: 10.1046/j.1537-2995.2002.00221.x

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