Article
Inactivation of parvovirus B19 during STIM-4 vapor heat treatment of three coagulation factor concentrates.
Transfusion - 1 Jun 2008
Berting Andreas, Modrof Jens, Unger Ulrike, Gessner Matthias, Klotz Andreas, Poelsler Gerhard, Kreil Thomas R
Abstract excerpt
BACKGROUND: To enhance the viral safety margins, nanofiltration has been widely integrated into the manufacturing process of plasma-derived medicinal products. Removal of smaller agents such as parvovirus B19 (B19V) by filtration, however, is typically less efficient. Because recent investigations have demonstrated that B19V may be more heat sensitive than animal parvoviruses, the potential B19V inactivation by a...
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