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Expression profiling of CD34 <sup>+</sup> hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia

4 Nov 2002

Abstract excerpt

One of the most serious consequences of cytotoxic cancer therapy is the development of therapy-related acute myeloid leukemia (t-AML), a neoplastic disorder arising from a multipotential hematopoietic stem cell. To gain insights into the molecular basis of this disease, we performed gene expression profiling of CD34(+) hematopoietic progenitor cells from t-AML patients. Our analysis revealed that there are...

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PMID: 12417757
DOI: 10.1073/pnas.222491799

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