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The molecular signature of MDS stem cells supports a stem-cell origin of 5q− myelodysplastic syndromes

6 Jul 2007

Abstract excerpt

Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cells. Expression of BMI1, encoding a critical regulator of self-renewal, was up-regulated in 5q-...

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PMID: 17616640
DOI: 10.1182/blood-2007-03-079368

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