Article
Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty.
Biochemical and molecular medicine - 1 Aug 1996
Laue L, Wu S M, Kudo M, Hsueh A J, Cutler G B, Jelly D H, Diamond F B, Chan W Y
Abstract excerpt
Male-limited precocious puberty (MPP) is a gonadotropin-independent disorder that occurs sporadically or is inherited in an autosomal dominant, male-limited pattern. Recent studies have identified constitutively activating missense mutations in the human luteinizing hormone receptor (hLHR) gene l...
Topics
- Amino Acid Sequence
- Black People
- Cells, Cultured
- Child, Preschool
- Cyclic AMP
- Humans
- Kidney
- Male
- Molecular Sequence Data
- Mutation
- Puberty, Precocious
- Receptors, LH
- Recombinant Proteins
- Sequence Analysis, DNA
- Black or African American