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Article

Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty.

Biochemical and molecular medicine - 1 Aug 1996

Laue L, Wu S M, Kudo M, Hsueh A J, Cutler G B, Jelly D H, Diamond F B, Chan W Y

Abstract excerpt

Male-limited precocious puberty (MPP) is a gonadotropin-independent disorder that occurs sporadically or is inherited in an autosomal dominant, male-limited pattern. Recent studies have identified constitutively activating missense mutations in the human luteinizing hormone receptor (hLHR) gene leading to Leydig cell activation and precocious puberty. Patients with sporadic MPP (SMPP) or with different ethnic...

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Identifiers

PMID: 8812739
DOI: 10.1006/bmme.1996.0048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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