Article
Association of vitamin D receptor gene polymorphism with renal cell carcinoma in Japanese.
Endocrine journal - 1 Aug 2002
Ikuyama Toshihiro, Hamasaki Takashi, Inatomi Hisato, Katoh Takahiko, Muratani Tetsuro, Matsumoto Tetsuro
Abstract excerpt
Molecular epidemiologic studies have reported a relationship between 1alpha,25 dihydroxyvitamin D3 (1,25(OH)2D3) and the development and progression of malignant tumors. (1,25(OH)2D3) exerts its biological activity by binding the vitamin D receptor (VDR), while recent studies have demonstrated that VDR gene polymorphisms affect serum levels of (1,25(OH)2D3). Serum levels of (1,25(OH)2D3) are reported to be...
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