Possible involvement of <i>hMLH1, p16</i>^<i>INK4a</i> and <i>PTEN</i> in the malignant transformation of endometriosis

Abstract excerpt

Endometriosis is a common gynecologic disease, which generally follows a benign course. Notwithstanding, several clinical and histologic studies as well as molecular data show that endometriosis could be a precursor of sporadic endometrioid and clear cell carcinomas at extrauterine loci. Several reports have implicated alterations of the hMLH1 and p16(ink4a) (p16) genes, in particular hypermethylation of the...

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