Article
<i>In vivo</i> angiogenic activity of neuroblastoma correlates with <i>MYCN</i> oncogene overexpression
7 Oct 2002
Abstract excerpt
Neuroblastoma (NB) is the most common malignant solid tumor in early childhood. Amplification of the MYCN oncogene is associated with a more malignant course of disease and poor outcome. The role that MYCN plays in the regulation of angiogenesis in NB remains unclear. To better elucidate this matter, fresh biopsy samples from 21 patients, 10 with MYCN-amplified tumors (defined as having >10 copies of the...
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