Article
A zebrafish sox9 gene required for cartilage morphogenesis.
Development (Cambridge, England) - 1 Nov 2002
Yan Yi-Lin, Miller Craig T, Nissen Robert M, Singer Amy, Liu Dong, Kirn Anette, Draper Bruce, Willoughby John, Morcos Paul A, Amsterdam Adam, Chung Bon-Chu, Westerfield Monte, Haffter Pascal, Hopkins Nancy, Kimmel Charles, Postlethwait John H, Nissen Robert
Abstract excerpt
The molecular genetic mechanisms of cartilage construction are incompletely understood. Zebrafish embryos homozygous for jellyfish (jef) mutations show craniofacial defects and lack cartilage elements of the neurocranium, pharyngeal arches, and pectoral girdle similar to humans with campomelic dysplasia. We show that two alleles of jef contain mutations in sox9a, one of two zebrafish orthologs of the human...
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