Article
A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Sept 2002
Schmidt Peter, Kühn Christa, Maillard Jean-Charles, Pitra Christian, Tiemann Ute, Weikard Rosemarie, Schwerin Manfred
Abstract excerpt
This study aimed to identify interferon-gamma (IFN-gamma) gene variants in cattle for diagnostic purposes. Therefore, the entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced. The BoIFNG DNA sequence conforms to the published part of Bo-IFN-gamma cDNA. Primer extension experiments show the presence of a 5' extension of exon 1 by 42 nucleotides (nt). One SINE element (Bov-A2) is...
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