A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non–homologous to the<i>ace</i>gene<i>Drosophila</i>

Abstract excerpt

Acetylcholinesterase (AChE) is the target of two major insecticide families, organophosphates (OPs) and carbamates. AChE insensitivity is a frequent resistance mechanism in insects and responsible mutations in the ace gene were identified in two Diptera, Drosophila melanogaster and Musca domestica. However, for other insects, the ace gene cloned by homology with Drosophila does not code for the insensitive AChE...

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