Article
Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy in zidovudine-experienced patients.
Journal of acquired immune deficiency syndromes (1999) - 1 Oct 2002
Shulman Nancy S, Hughes Michael D, Winters Mark A, Shafer Robert W, Zolopa Andrew R, Hellmann Nicholas S, Bates Michael, Whitcomb Jeannette M, Katzenstein David A
Abstract excerpt
To identify the level of phenotypic susceptibility for stavudine (d4T) that is associated with a diminished virologic response to d4T therapy, phenotyping was performed on archived baseline HIV isolates from 26 subjects who received d4T monotherapy in AIDS Clinical Trials Group (ACTG) 302 who had received >3 years of prior zidovudine (ZDV) monotherapy. Seven of 26 subjects achieved a virologic response of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.