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Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML

26 Sept 2012

Abstract excerpt

A hallmark of cancer is the disruption of differentiation within tumor cells. Internal tandem duplication mutations of the FLT3 kinase (FLT3/ITD) occur commonly in acute myeloid leukemia (AML) and are associated with poor survival, leading to efforts to develop FLT3 kinase inhibitors. However, FLT3 inhibitors have thus far met with limited success, inducing only a clearance of peripheral blasts with minimal BM...

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Identifiers

PMID: 23012328
DOI: 10.1182/blood-2012-01-402545

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