Article
HLA-DR antigen frequencies in Mexican patients with dengue virus infection: HLA-DR4 as a possible genetic resistance factor for dengue hemorrhagic fever.
Human immunology - 1 Nov 2002
LaFleur Curtis, Granados Julio, Vargas-Alarcon Gilberto, Ruíz-Morales Jorge, Villarreal-Garza Cynthia, Higuera Lorena, Hernández-Pacheco Guadalupe, Cutiño-Moguel Teresa, Rangel Hilda, Figueroa Raymunda, Acosta Maribel, Lazcano Eduardo, Ramos Celso
Abstract excerpt
The human leukocyte antigen DRB1 locus (HLA-DRB1) was typed in genomic DNA extracted from whole blood samples of 34 Mexican dengue hemorrhagic fever (DHF) patients and 47 dengue fever (DF) patients, by polymerase chain reaction-sequence-specific oligonucleotide reverse dot blot. HLA-DRB1*04 was negatively associated with risk of DHF (OR 0.31, 95% CI 0.11-0.85). HLA-DR4 homozygous individuals were 11.6 times less...
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