Article
Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy.
Liver - 1 Oct 2002
Constantini Patricia K, Wawrzynowicz-Syczewska Marta, Clare Michael, Boron-Kaczmarska Anna, McFarlane Ian G, Cramp Mathew E, Donaldson Peter T
Abstract excerpt
BACKGROUND/AIMS: Though there is a consensus that the HLA DQB1*0301 allele is important in untreated HCV clearance, this association is not universal and a number of genes outside the major histocompatibility complex may also play a role in host responses to HCV infection. Prime candidates, at present, are the genes encoding pro-inflammatory and immuno-regulatory cytokines. The aim of this study was to...
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