Article
Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure.
The Journal of general virology - 1 Nov 2002
Mercer A A, Wise L M, Scagliarini A, McInnes C J, Büttner M, Rziha H J, McCaughan C A, Fleming S B, Ueda N, Nettleton P F
Abstract excerpt
The first report of a vascular endothelial growth factor (VEGF)-like gene in Orf virus included the surprising observation that the genes from two isolates (NZ2 and NZ7) shared only 41.1% amino acid sequence identity. We have examined this sequence disparity by determining the VEGF gene sequence of 21 isolates of Orf virus derived from diverse sources. Most isolates carried NZ2-like VEGF genes but their predicted...
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