Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective intestinal cobalamin malabsorption with proteinuria (Imerslund-Gräsbeck syndrome) in juvenile Beagles.

Journal of veterinary internal medicine - 1 Jan 2000

Fyfe J C, Hemker S L, Venta P J, Stebbing B, Giger U

Abstract excerpt

BACKGROUND: Selective intestinal cobalamin malabsorption with mild proteinuria (Imerslund-Gräsbeck syndrome; I-GS), is an autosomal recessive disorder of dogs caused by mutations in AMN or CUBN that disrupt cubam function and which can present as a medical emergency. OBJECTIVES: To describe the clinical, metabolic, and genetic bases of I-GS in Beagles. ANIMALS: Four cobalamin-deficient and 43 clinically normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Megaloblastic
Share to Dog Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Malabsorption Syndromes

Share to Membrane Glycoproteins

Share to Proteinuria

Share to Vitamin B 12 Deficiency

Source

Open in PubMed Open full text

Identifiers

PMID: 24433284
DOI: 10.1111/jvim.12284
PMCID: PMC3959579

Genes

CUBN
AMN
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective intestinal cobalamin malabsorption with proteinuria (Imerslund-Gräsbeck syndrome) in juvenile Beagles.PMID 24433284Read ↗

A Frameshift Mutation in the Cubilin Gene (CUBN) in Border Collies with Imerslund-Gräsbeck Syndrome (Selective Cobalamin Malabsorption)Semantic proximity Read ↗

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.Semantic proximity Read ↗

Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndromeSemantic proximity Read ↗

Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption.Semantic proximity Read ↗

Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q.Semantic proximity Read ↗

Failure to thrive and life-threatening complications due to inherited selective cobalamin malabsorption effectively managed in a juvenile Australian shepherd dog.Semantic proximity Read ↗

“Cytopenias and proteinuria as key diagnostic features of Imerslund-Gräsbeck Syndrome: a case series of four Argentine patients”Semantic proximity Read ↗

An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogsSemantic proximity Read ↗

A frameshift mutation in the cubilin gene (<i><scp>CUBN</scp></i>) in <scp>B</scp>eagles with <scp>I</scp>merslund–<scp>G</scp>räsbeck syndrome (selective cobalamin malabsorption)Semantic proximity Read ↗

Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns.Semantic proximity Read ↗

<i>SLC3A1</i> and <i>SLC7A9</i> Mutations in Autosomal Recessive or Dominant Canine Cystinuria: A New Classification SystemSemantic proximity Read ↗

Benign proximal tubular albuminuria due to AMN mutation: A challenging presentation of Imerslund-Gräsbeck syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.