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Article

Mesangial cell-predominant gene, megsin

1 Sept 2002

Abstract excerpt

We identified a novel gene, termed megsin, predominantly expressed in mesangial cells utilizing a 3'-directed regional cDNA library from cultured human mesangial cells. Megsin is a novel serine protease inhibitor (serpin), and the level of megsin RNA/protein expression is up-regulated in patients with IgA nephropathy or diabetic nephropathy, suggesting a link between megsin expression and the pathogenesis of...

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PMID: 12386281
DOI: 10.1093/ndt/17.suppl_9.32

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