Article
[Association of single nucleotide polymorphism of megsin gene with IgA nephropathy].
Zhonghua yi xue za zhi - 23 May 2006
Wang Zhao-hui, Chen Nan, Pan Xiao-xia, Ren Hong, Wang Wei-ming, Zhang Wen, Hao Cui-lan, Zhu Jie, Lu Ying, Han Bin
Abstract excerpt
OBJECTIVE: To investigate whether the single nucleotide polymorphisms (SNPs) in the gene of megsin, a novel serine protease inhibitor, account for the pathogenicity of IgA nephropathy (IgAN). METHODS: A comprehensive megsin gene survey, including the entire coding region, part of the regulatory region, and exon-intron connection region, was performed by PCR-direct sequencing on the DNA samples of peripheral blood...
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