Article
Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos.
Toxicology letters - 15 Nov 2002
Lafuente M J, Casterad X, Laso N, Mas S, Panades R, Calleja A, Hernandez S, Turuguet D, Ballesta A, Ascaso C, Lafuente A
Abstract excerpt
Alpha 1 antitrypsin is a highly polymorphic anti-elastase enzyme, especially active in the protection of alveoli and liver. Here we studied the distribution of two deficient alleles Pi*Z and Pi* S, in 194 asbestos workers, of whom 100 were asbestosis cases, and 94 were controls without disease (exposed controls, EC). A second group of controls without asbestos exposure (non-exposed controls, NEC; n=122) was also...
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