Article
Sequence-specific interaction of nascent antiterminator RNA with the zinc-finger motif of Escherichia coli RNA polymerase.
Molecular microbiology - 1 Oct 2002
Sen Ranjan, King Rodney A, Mzhavia Nino, Madsen Peter L, Weisberg Robert A
Abstract excerpt
The N-terminal Zn-finger motif of the beta' subunit of RNA polymerase contains two pairs of invariant cysteines flanking a moderately well-conserved segment of 13 amino acids that is rich in basic residues. Previous work showed that replacement of certain Zn-finger residues prevented transcription antitermination in response to phage HK022 put sites. Nascent put RNA binds to and modifies transcribing polymerase,...
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