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Article

A Knock-In Reporter Model of Batten Disease

12 Sept 2007

Abstract excerpt

Juvenile neuronal ceroid lipofuscinosis is a severe inherited neurodegenerative disease resulting from mutations in CLN3 (ceroid-lipofuscinosis, neuronal 3, juvenile). CLN3 function, and where and when it is expressed during development, is not known. In this study, we generated a knock-in reporter mouse to elucidate CLN3 expression during embryogenesis and after birth and to correlate expression and behavior in...

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PMID: 17855597
DOI: 10.1523/jneurosci.1710-07.2007

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