Article
Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder.
Cellular and molecular neurobiology - 1 Apr 2002
Fatemi S Hossein, Stary Joel M, Egan Elizabeth Ann
Abstract excerpt
1. Autism is a severe neurodevelopmental disorder with potential genetic and environmental etiologies. Recent genetic linkage reports and biochemical analysis of postmortem autistic cerebellum point to Reelin, an important secretory extracellular protein, as being involved in the pathology of autism. 2. We hypothesized that blood levels of Reelin and its isoforms would be altered in autistic twins, and their...
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