Article
Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis.
Nature cell biology - 1 Oct 2002
Polesello Cédric, Delon Isabelle, Valenti Philippe, Ferrer Pierre, Payre François
Abstract excerpt
Ezrin, Radixin and Moesin (ERM) proteins are thought to constitute a bridge between the actin cytoskeleton and the plasma membrane (PM). Here we report a genetic analysis of Dmoesin, the sole member of the ERM family in Drosophila. We show that Dmoesin is required during oogenesis for anchoring microfilaments to the oocyte cortex. Alteration of the actin cytoskeleton resulting from Dmoesin mutations impairs the...
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