Article
Mutations in the dystrophin gene are associated with sporadic dilated cardiomyopathy.
Molecular genetics and metabolism - 1 Jan 2000
Feng Jinong, Yan Jin, Buzin Carolyn H, Towbin Jeffrey A, Sommer Steve S
Abstract excerpt
Dilated cardiomyopathy (DCM) is the major indication for heart transplantation. Approximately 30% of all DCM is thought to be inherited, while 70% is sporadic. Mutations in the dystrophin gene have been associated with the uncommon X-linked form of DCM. We hypothesized that missense mutations and other less severe mutations of the dystrophin gene might predispose to the common form of sporadic DCM. To test this...
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