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Article

Genotoxicity is modulated by ascorbic acid. Studies using the wing spot test in Drosophila.

Mutation research - 26 Sept 2002

Kaya Bülent, Creus Amadeu, Velázquez Antonia, Yanikoğlu Atila, Marcos Ricardo

Abstract excerpt

The ability of ascorbic acid (Vitamin C) to modulate the genotoxic action of several mutagens was investigated in the wing spot test of Drosophila melanogaster. In this assay, 3-day-old transheterozygous larvae for the multiple wing hairs (mwh, 3-0.3) and flare (flr, 3-38.8) genes were treated with three reference mutagenic compounds, namely cobalt chloride (CoCl2), 4-nitroquinoline 1-oxide (4-NQO) and potassium...

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PMID: 12297148
DOI: 10.1016/s1383-5718(02)00173-0

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