Article
Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension.
Circulation - 17 Sept 2002
Tiago Armindo D, Samani Nilesh J, Candy Geoffrey P, Brooksbank Richard, Libhaber Elena N, Sareli Pinhas, Woodiwiss Angela J, Norton Gavin R
Abstract excerpt
BACKGROUND: The extent to which genes modify the relationship between risk factors for hypertension and blood pressure (BP) is unclear. As angiotensinogen is expressed in adipose tissue and angiotensinogen (AGT) gene promoter variants influence the production of angiotensinogen, we evaluated the role of AGT gene variants as potential modifiers of body size-BP relations. METHODS AND RESULTS: Five hundred...
Topics
- Angiotensinogen
- Blood Pressure Monitoring, Ambulatory
- Body Constitution
- Body Mass Index
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hypertension
- Male
- Middle Aged
- Obesity
- Phenotype
- Polymorphism, Genetic