Article
Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis.
The Journal of rheumatology - 1 Sept 2002
Fabris Martina, Tolusso Barbara, Di Poi Emma, Assaloni Roberta, Sinigaglia Luigi, Ferraccioli Gianfranco
Abstract excerpt
OBJECTIVE: To define the frequency of the exon 6 tumor necrosis factor-alpha (TNF-alpha) receptor II (TNFRII) gene polymorphism in severe and mild-moderate rheumatoid arthritis (RA) and its possible influence on anti-TNF-alpha treatment responsiveness. METHODS: Two cohorts of patients with RA, the first (n = 97) defined as methotrexate responders (MTX-R) with mild-moderate synovitis, and the second (n = 78)...
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