Article
An association study of a functional catalase gene polymorphism, -262C-->T, and patients with Alzheimer's disease.
Neuroscience letters - 20 Sept 2002
Goulas Antonis, Fidani Liana, Kotsis Alexandros, Mirtsou Vassiliki, Petersen Ronald C, Tangalos Eric, Hardy John
Abstract excerpt
According to the oxidative stress hypothesis which has been proposed as one of a number of possible mechanisms underlying pathogenesis of Alzheimer's disease (AD), accumulation of hydrogen peroxide in the brain of affected individuals, due to overproduction and/or insufficient detoxification, can trigger a cascade of neurotoxic events, thus contributing to the neuronal damage characteristic of the disease. The...
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