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Article

Animal models for skin blistering conditions: absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse.

The Journal of investigative dermatology - 1 Sept 2002

Spirito Flavia, Charlesworth Alexandra, Linder Keith, Ortonne Jean-Paul, Baird John, Meneguzzi Guerrino

Abstract excerpt

Recent achievements in the genetic correction of keratinocytes isolated from patients with junctional epidermolysis bullosa have paved the way to a gene therapy approach for the disease. Because gene therapy protocols require preclinical validation in animals, we have characterized spontaneous animal models of junctional epidermolysis bullosa. In this study we have elucidated the genetic basis of the hereditary...

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Source

Identifiers

PMID: 12230513
DOI: 10.1046/j.1523-1747.2002.01852.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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