Article
A mutation in bovine keratin 5 causing epidermolysis bullosa simplex, transmitted by a mosaic sire.
The Journal of investigative dermatology - 1 Jun 2005
Ford Christine A, Stanfield Angela M, Spelman Richard J, Smits Bronwyn, Ankersmidt-Udy Alexandra E L, Cottier Kenneth, Holloway Hilary, Walden Adrian, Al-Wahb Muhannad, Bohm Elizabeth, Snell Russell G, Sutherland Greg T
Abstract excerpt
A mechanobullous skin disorder was identified in the progeny of a 3-y-old Friesian-Jersey crossbred bull. The condition presented as loss of skin and mucosa from contact areas and inflammation. Examination of skin samples under light microscopy revealed separation of the epidermis from the dermis. Electron microscopic analysis refined the site of cleavage to above the basement membrane involving lysis of basal...
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