Article
Phenotype of hepatocyte spheroids in Arg-GLY-Asp (RGD) containing a thermo-reversible extracellular matrix.
Bioscience, biotechnology, and biochemistry - 1 Jul 2002
Park Keun-Hong, Bae You Han
Abstract excerpt
The spheroid of specific cells is often regarded as the better form in artificial organs and mammalian cell bioreactors for improved cell-specific functions. In this study, freshly harvested primary rat hepatocytes, which had been cultivated as spheroids and entrapped in a synthetic thermo-reversible extracellular matrix, were examined for differentiated morphology and enhanced liver-specific functions as...
Topics
- Acrylic Resins
- Animals
- Cell Adhesion Molecules
- Cell Separation
- Cell Survival
- Extracellular Matrix
- Gels
- Hepatocytes
- In Vitro Techniques
- Ligands
- Liver
- Molecular Weight