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Article

Mutation or deletion of the C-terminal tail affects the function and structure of Xenopus laevis small heat shock protein, hsp30.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Sept 2002

Fernando P, Abdulle R, Mohindra A, Guillemette J G, Heikkila J J

Abstract excerpt

Small heat shock proteins (shsps) act as molecular chaperones by preventing heat-induced aggregation and unfolding of cellular proteins by a mechanism that is still unclear. Previously we found that the C-terminal end of Xenopus shsp, hsp30C (30C), was essential for optimal chaperone activity. Examination of the C-terminal tail of 30C revealed that it had a net negative charge. Involvement of this negative charge...

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PMID: 12223216
DOI: 10.1016/s1096-4959(02)00110-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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