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Article

Modulation of cellular cholesterol transport and homeostasis by Rab11.

Molecular biology of the cell - 1 Sept 2002

Hölttä-Vuori Maarit, Tanhuanpää Kimmo, Möbius Wiebke, Somerharju Pentti, Ikonen Elina

Abstract excerpt

To analyze the contribution of vesicular trafficking pathways in cellular cholesterol transport we examined the effects of selected endosomal Rab proteins on cholesterol distribution by filipin staining. Transient overexpression of Rab11 resulted in prominent accumulation of free cholesterol in Rab11-positive organelles that sequestered transferrin receptors and internalized transferrin. Sphingolipids were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

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Share to rab GTP-Binding Proteins

Share to Receptors, Transferrin

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Source

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Identifiers

PMID: 12221119
DOI: 10.1091/mbc.e02-01-0025
PMCID: PMC124146

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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