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Article

Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.

The Journal of biological chemistry - 30 Jun 2006

Ganley Ian G, Pfeffer Suzanne R

Abstract excerpt

Niemann-Pick type C disease is an autosomal recessive disorder that leads to massive accumulation of cholesterol and glycosphingolipids in late endosomes and lysosomes. To understand how cholesterol accumulation influences late endosome function, we investigated the effect of elevated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment. Endogenous Rab9 levels were elevated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16644737
DOI: 10.1074/jbc.M601679200
PMCID: PMC3650718

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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