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Article

Age-related changes in human bone proteoglycan structure. Impact of osteogenesis imperfecta.

The Journal of biological chemistry - 15 Nov 2002

Grzesik Wojciech J, Frazier Chester R, Shapiro Jay R, Sponseller Paul D, Robey Pamela Gehron, Fedarko Neal S

Abstract excerpt

Proteoglycans (PGs) are a family of molecules that undergo extensive post-translational modifications that include addition of glycosaminoglycan (GAG) chains as well as N- and O-linked oligosaccharides to the protein core. PG composition and structure have been reported to alter with age. To test whether the post-translational modifications to PGs can serve as in vitro surrogate end point markers for...

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Identifiers

PMID: 12221073
DOI: 10.1074/jbc.M202124200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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