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Article

ilvIH operon expression in Escherichia coli requires Lrp binding to two distinct regions of DNA.

Journal of bacteriology - 1 Oct 2002

Jafri Samina, Chen Shaolin, Calvo Joseph M

Abstract excerpt

The leucine-responsive regulatory protein Lrp regulates the expression of a number of operons in Escherichia coli, including the ilvIH operon. Earlier in vitro experiments showed purified Lrp binding to two regions of DNA proximal to the ilvIH promoter, an upstream region (-260 to -190) and a downstream region (-150 to -40). The effect of mutations in these regions on ilvIH promoter expression in vivo led to the...

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Identifiers

PMID: 12218014
DOI: 10.1128/JB.184.19.5293-5300.2002
PMCID: PMC135361

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Source receipt: pubmed, retrieved 7 Sept 2026.

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