Article
Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional apolipoprotein e genotype.
The Journal of clinical endocrinology and metabolism - 1 Sept 2002
Lehtimäki Terho, Dastidar Prasun, Jokela Hannu, Koivula Timo, Lehtinen Saara, Ehnholm Christian, Punnonen Reijo
Abstract excerpt
Apolipoprotein (apo)E gene epsilon4 allele carrier status modulates the responses of lipoprotein metabolism to hormone-replacement therapy (HRT). We investigated the effect of long-term HRT on the progression of atherosclerosis in postmenopausal women with or without apoE epsilon4 allele. One hundred forty-one nonsmoking postmenopausal women, 45-71 yr old, were divided into 3 groups based on the use of HRT. The...
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