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Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2002

Wu Ruey-Meei, Shan Din-E, Sun Chen-Ming, Liu Ren-Shyan, Hwu Wuh-Liang, Tai Chun-Hwei, Hussey Jennifer, West Andrew, Gwinn-Hardy Katrina, Hardy John, Chen Judy, Farrer Matt, Lincoln Sarah

Abstract excerpt

We report on clinical (18)F-labeled 6-fluorodopa ((18)F-dopa) positron emission tomography (PET) and molecular genetic analyses of an ethnic Chinese family in which three siblings presented with early-onset Parkinson's disease. As described in some parkin patients, neither sleep benefit nor diurnal fluctuation was noted. Interestingly, depression, anxiety, and obsessive-compulsive disorders were manifest. The...

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PMID: 12210855
DOI: 10.1002/mds.10184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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