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Article

Going malignant: the hypoxia-cancer connection in the prostate.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 2002

Hochachka P W, Rupert J L, Goldenberg L, Gleave M, Kozlowski P

Abstract excerpt

The metabolic organization of both normal and malignant prostate cellular phenotypes involves some unusual and surprising features. In particular, both conditions exhibit ratios of NADH/NAD+ and NADPH/NADP+ characteristic of high oxidative states despite a chronic shortage of O2 in both conditions. In this paper, we observe that, in prostate cancer cells, the oxidizing power of the fatty acid synthesis (FAS)...

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Identifiers

PMID: 12210536
DOI: 10.1002/bies.10131

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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