Article
Effects of glucose on cloning efficiency and mutagenesis of fetal rat cells.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 2002
Donovan Paul J, Smith George T, Riggs Charles W, Alexandrov Valerii A
Abstract excerpt
In a previous study, treatment of rats with 10% glucose in the drinking water, as fetuses during gestation and for 1.5 months after delivery, significantly enhanced tumor incidence that resulted from N-methyl-N-nitrosourea (MNU, 20 mg/kg) given transplacentally on gestation day 21, with a 1.6-fold increase in overall tumor incidence. We investigated whether glucose would have an effect on MNU-induced mutation in...
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